tag:blogger.com,1999:blog-2228450388044990797.post2235047632540234056..comments2023-10-30T04:34:01.166-07:00Comments on Darwin's students: Evolutionary Trade-Offs:Sickle Cell Disease and MalariaMark Pallenhttp://www.blogger.com/profile/06911675151032525386noreply@blogger.comBlogger3125tag:blogger.com,1999:blog-2228450388044990797.post-26920423971046239542018-05-16T04:43:48.611-07:002018-05-16T04:43:48.611-07:00THERE IS A CURE TO SICKLE CELL ANEMIA, AM A LIVING...THERE IS A CURE TO SICKLE CELL ANEMIA, AM A LIVING TESTIMONY.<br /><br />I write to you with great joy in my heart how Dr Alegbe John turned my life around. I was born a sickle cell patient through the gene- type of my parents and became a carrier which led to immense crises all through my growing up years. This particular ailment was called rheumatism, the pain of the bone which I was told was caused by difficult circulation of blood in the vein axis.<br /><br />Growing up was like hell because apart from the pain and the fear of it, I also lived in bondage for years before Dr Alegbe intervention.<br /><br />I was restricted from doing what my mates could do, there was a lot of don’t touch, don’t eat, don’t go, don’t wear by the doctor and I lived all through this period on drugs. I was made to know that without this pill, my life will would finally come to an end. It was total bondage.<br /><br />During this period of pain, I would cry, shout, throw myself to the ground, destroy things I could find around me just because of restlessness the pain caused. My Dad got the contact of Dr Alegbe from the internet and he emailed him told him about me and made purchase from his product. I too the medication for one month and he always call to know how am feeling, that was how i was cured completely. any one can reach him On his gmail address at dralegbe@gmail.com<br /><br /> I stopped taking my drugs because Dr Alegbe John has made me completely cured, I no longer feel pain neither do I remember how it feels.Anonymoushttps://www.blogger.com/profile/17444148049971611791noreply@blogger.comtag:blogger.com,1999:blog-2228450388044990797.post-76359319597151920982010-06-21T22:31:09.053-07:002010-06-21T22:31:09.053-07:00It is amazing how viruses evolve to the extent tha...It is amazing how viruses evolve to the extent that they are indestructible for us ... in a ocacion saw a documentary called <a href="http://www.softcialis.net/" title="buy cialis" rel="nofollow">buy cialis</a><br /> and talked about how medicine is moving to eliminate bacteria and viruses that are resistant to antibiotics even so .. we could not remove them ..... thanks!Kimberlyhttps://www.blogger.com/profile/07692441059460235876noreply@blogger.comtag:blogger.com,1999:blog-2228450388044990797.post-8976593973167361562009-02-19T13:12:00.000-08:002009-02-19T13:12:00.000-08:00AFAIK this same approach is also tested as a treat...AFAIK this same approach is also tested as a treatment in cases of multiple resistance against antibiotics. First "select" bacteria which are resistant against a certain combination of antibiotics, than treat with a different antibiotic that targets a "weakness" (which is the result of a trade-off) that is connected with resistance to this antibiotics.<BR/><BR/>There're a lot of examples regarding trade-offs if you look at immunology. Your major histocompatibility type (in humans called HLA (human leukocyte antigen) type) <A HREF="http://scholar.google.com/scholar?q=hla+susceptibility+disease&hl=de&lr=&btnG=Suche&lr=" REL="nofollow">can determine your susceptibility to certain diseases</A>. <BR/><BR/>It is proposed that it is advantageous for a population to have a high MHC diversity because that ensures that at least some individuals in a population do have a resistance to certain diseases and it has been proposed that the <A HREF="http://www.ncbi.nlm.nih.gov/pubmed/15755811" REL="nofollow">MHC type is even influencing mate choice</A> - the more diverse, the better.<BR/>So, the same MHC type can be protective against infection with one class of germs but OTOH makes you more susceptible for another kind of disease.<BR/><BR/>Antoher example of immunology-related trade-offs is the <A HREF="http://en.wikipedia.org/wiki/CCR5" REL="nofollow">CCR5 mutation that provides protection against HIV infection</A>: "The allele has a negative effect upon T cell function, but appears to protect against smallpox and HIV. Yersinia pestis was demonstrated in the laboratory to not associate with CCR5. Individuals with the Δ32 allele of CCR5 are healthy, suggesting that CCR5 is largely dispensable. However, CCR5 apparently plays a role in mediating resistance to West Nile virus infection in humans, as CCR5-Δ32 individuals have shown to be disproportionately at higher risk of West Nile virus in studies,[7] indicating that not all of the functions of CCR5 may be compensated by other receptors."<BR/>In this case, lower risk of being affected by HIV and small pox is coupled with a higher risk of getting affected by West nile virus (and of course, possibly other viruses as well).<BR/><BR/>All the best,<BR/>Sabine aka JLTJLThttps://www.blogger.com/profile/08207057712039374725noreply@blogger.com